ARG44539
anti-LTB antibody
anti-LTB antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LTB |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | LTB |
| Antigen Species | Human |
| Immunogen | Synthetic peptide from Human |
| Conjugation | Un-conjugated |
| Alternate Names | LTB; Lymphotoxin Beta; TNFSF3; TNFC; P33; Tumor Necrosis Factor Ligand Superfamily Member 3; TNF Superfamily Member 3; Necrosis Factor C; Lymphotoxin-Beta; LT-Beta; TNF-C |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 40% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | LTB |
| Gene Full Name | Lymphotoxin Beta |
| Background | Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Function | Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. |
| Cellular Localization | Membrane |
| Calculated MW | 25 kDa |
Images (2) Click the Picture to Zoom In
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ARG44539 anti-LTB antibody IHC-P image
Immunohistochemistry: Human liver stained with ARG44539 anti-LTB antibody.
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ARG44539 anti-LTB antibody IHC-P image
Immunohistochemistry: Human tonsils stained with ARG44539 anti-LTB antibody.
