ARG66601
anti-LYVE1 antibody
anti-LYVE1 antibody for Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Publication1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LYVE1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-Fr, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | LYVE1 |
| Antigen Species | Human |
| Immunogen | Recombinant Human LYVE1. |
| Conjugation | Un-conjugated |
| Alternate Names | Lymphatic vessel endothelial hyaluronic acid receptor 1; Hyaluronic acid receptor; LYVE-1; XLKD1; HAR; Extracellular link domain-containing protein 1; CRSBP-1; Cell surface retention sequence-binding protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y5Y7 Human Lymphatic vessel endothelial hyaluronic acid receptor 1 |
|---|---|
| Gene Symbol | LYVE1 |
| Gene Full Name | lymphatic vessel endothelial hyaluronan receptor 1 |
| Background | This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008] |
| Function | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. [UniProt] |
| Calculated MW | 35 kDa |
| PTM | O-glycosylated. [UniProt] |
Images (4) Click the Picture to Zoom In
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ARG66601 anti-LYVE1 antibody IHC-Fr image
Immunohistochemistry: Cryo sections of Human colon carcinoma tissue stained with ARG66601 anti-LYVE1 antibody (red) and anti-Human CD31 (green). A: CD31; B: LYVE1; C: Merged.
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ARG66601 anti-LYVE1 antibody WB image
Western blot: Recombinant Human sLYVE1 and Mouse sLYVE1 stained with ARG66601 anti-LYVE1 antibody. There is more or less no cross reactivity with Mouse LYVE1.
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ARG66601 anti-LYVE1 antibody FACS image
Flow Cytometry: Human dermal microvascular endothelial cells (HDMVEC) stained with ARG66601 anti-LYVE1 antibody.
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ARG66601 anti-LYVE1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human intestine (border area of a colon carcinoma) stained with ARG66601 anti-LYVE1 antibody.
Specific References
BRAF V600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs
IHC-P / Human
