Overview

Product Description	Rabbit Polyclonal antibody recognizes MALT1
Tested Reactivity	Hu
Tested Application	FACS, ICC/IF, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	MALT1
Antigen Species	Human
Immunogen	Synthetic peptide derived from Human MALT1.
Conjugation	Un-conjugated
Alternate Names	MALT lymphoma-associated translocation; Paracaspase; MLT1; MLT; EC 3.4.22.-; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; IMD12

Application Instructions

Application Suggestion	Tested Application Dilution FACS 1:60 ICC/IF 1:50 - 1:200 WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	Jurkat
Observed Size	~ 92 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 10892 Human MALT1 Swiss-port # Q9UDY8 Human Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Gene Symbol	MALT1
Gene Full Name	MALT1 paracaspase
Background	This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Function	Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. [UniProt]
Cellular Localization	Nucleus. [UniProt]
Calculated MW	92 kDa

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