ARG45877
anti-MBD3 antibody
anti-MBD3 antibody for Western blot,ICC/IF and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MBD3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MBD3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to C-terminal region of human MBD3. |
| Conjugation | Un-conjugated |
| Alternate Names | Methyl-CpG Binding Domain Protein 3; MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 33 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -22°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O95983 Human Methyl-CpG-binding domain protein 3 Swiss-port # Q9Z2D8 Mouse Methyl-CpG-binding domain protein 3 |
|---|---|
| Gene Symbol | MBD3 |
| Gene Full Name | Methyl-CpG Binding Domain Protein 3 |
| Background | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. [UniProt] |
| Cellular Localization | Chromosome; Nucleus. [UniProt] |
| Calculated MW | 32 kDa |
| PTM | Isopeptide bond; Phosphoprotein; Ubl conjugation. [UniProt] |
