ARG44203
anti-MMACHC / CblC antibody
anti-MMACHC / CblC antibody for Flow cytometry,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MMACHC / CblC |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MMACHC / CblC |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human MMACHC / CblC |
| Conjugation | Un-conjugated |
| Protein Full Name | Cyanocobalamin reductase / alkylcobalamin dealkylase |
| Alternate Names | MMACHC; Metabolism Of Cobalamin Associated C; CblC; Methylmalonic Aciduria (Cobalamin Deficiency) CblC Type, With Homocystinuria; Methylmalonic Aciduria And Homocystinuria Type C Protein; Cyanocobalamin Reductase / Alkylcobalamin Dealkylase; Cyanocobalamin Reductase (Cyanide-Eliminating); Alkylcobalamin:Glutathione S-Alkyltransferase; DKFZP564I122; EC 2.5.1.151; EC 1.16.1.6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y4U1 Human Methylmalonic aciduria and homocystinuria type C protein |
|---|---|
| Gene Symbol | MMACHC |
| Gene Full Name | Metabolism Of Cobalamin Associated C |
| Background | The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC. |
| Function | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. |
| Cellular Localization | Cytoplasm |
| Calculated MW | 32 kDa |
| PTM | Phosphoprotein |
Images (2) Click the Picture to Zoom In
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ARG44203 anti-MMACHC / CblC antibody WB image
Western blot: K562 stained with ARG44203 anti-MMACHC / CblC antibody at 0.5 μg/mL dilution.
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ARG44203 anti-MMACHC / CblC antibody FACS image
Flow Cytometry: JK stained with ARG44203 anti-MMACHC / CblC antibody at 1 μg/1x10^6 cells dilution.
