Overview

Product Description	Rabbit Polyclonal antibody recognizes MRP2
Tested Reactivity	Hu
Tested Application	FACS, ICC/IF, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	MRP2
Antigen Species	Human
Immunogen	Synthetic peptide derived from Human MRP2.
Conjugation	Un-conjugated
Alternate Names	DJS; ATP-binding cassette sub-family C member 2; CMOAT; ABC30; cMRP; Canalicular multidrug resistance protein; MRP2; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2

Application Instructions

Application Suggestion	Tested Application Dilution FACS 1:100 ICC/IF 1:50 - 1:200 WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	HepG2

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 1244 Human ABCC2 Swiss-port # Q92887 Human Canalicular multispecific organic anion transporter 1
Gene Symbol	ABCC2
Gene Full Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Background	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
Function	Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. [UniProt]
Cellular Localization	Apical cell membrane > Multi-pass membrane protein. [UniProt]
Calculated MW	174 kDa

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