ARG67267
anti-Mesothelin antibody [SQab30383]
anti-Mesothelin antibody [SQab30383] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Monoclonal antibody [SQab30383] recognizes Mesothelin. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30383 |
| Isotype | IgG |
| Target Name | Mesothelin |
| Immunogen | Synthetic peptide. |
| Conjugation | Un-conjugated |
| Alternate Names | MSLN; Mesothelin; MPF; Pre-Pro-Megakaryocyte-Potentiating Factor; CAK1 Antigen; CAK1; Soluble MPF Mesothelin Related Protein; Megakaryocyte Potentiating Factor; SMRP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MSLN |
| Gene Full Name | Mesothelin |
| Background | This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] |
| Function | Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. [Uniprot] |
| Cellular Localization | Cell membrane, Golgi apparatus, Membrane, Secreted. [Uniprot] |
| Calculated MW | 69 kDa |
| PTM | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein. [Uniprot] |
