ARG45214
anti-Mkl1 / MRTFA antibody
anti-Mkl1 / MRTFA antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Mkl1 / MRTFA |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Mkl1 / MRTFA |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human Mkl1 / MRTFA. |
| Conjugation | Un-conjugated |
| Alternate Names | MRTFA; Myocardin Related Transcription Factor A; MRTF-A; MAL; KIAA1438; BSAC; MKL1; MKL; Megakaryoblastic Leukemia (Translocation) 1; Myocardin-Related Transcription Factor A; Megakaryocytic Acute Leukemia Protein; Megakaryoblastic Leukemia 1 Protein; Basic, SAP And Coiled-Coil Domain; MKL/Myocardin-Like Protein 1; Megakaryocytic Acute Leukemia; Alternative Protein MKL1 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 145 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MRTFA |
| Gene Full Name | Myocardin Related Transcription Factor A |
| Background | The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| Function | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 98 kDa |
| PTM | Phosphoprotein. [UniProt] |
