ARG45411
anti-NDFIP2 antibody [10D6D7]
anti-NDFIP2 antibody [10D6D7] for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes NDFIP2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 10D6D7 |
| Isotype | IgG2b |
| Target Name | NDFIP2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human NDFIP2. |
| Conjugation | Un-conjugated |
| Alternate Names | NDFIP2; Nedd4 Family Interacting Protein 2; KIAA1165; N4wbp5a; Putative MAPK-Activating Protein PM04/PM05/PM06/PM07; Putative NF-Kappa-B-Activating Protein 413; NEDD4 Family-Interacting Protein 2; NEDD4 WW Domain-Binding Protein 5A; MAPK-Activating Protein PM04 PM05 PM06 PM07; NF-Kappa-B-Activating Protein 413; N4WBP5A |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 39 kDa |
Properties
| Form | Powder |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9NV92 Human NEDD4 family-interacting protein 2 |
|---|---|
| Gene Symbol | NDFIP2 |
| Gene Full Name | Nedd4 Family Interacting Protein 2 |
| Background | Enables WW domain binding activity. Involved in negative regulation of gene expression; negative regulation of transport; and positive regulation of protein ubiquitination. Located in several cellular components, including Golgi apparatus; mitochondrion; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024] |
| Function | Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. [UniProt] |
| Cellular Localization | Endosome; Golgi apparatus; Membrane. [UniProt] |
| Calculated MW | 36 kDa |
| PTM | Phosphoprotein; Ubl conjugation. [UniProt] |
