ARG54088
anti-NUP98 antibody
anti-NUP98 antibody for Immunoprecipitation,Western blot and Human
Gene Regulation antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes NUP98 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | NUP98 |
| Antigen Species | Human |
| Immunogen | Purified recombinant human NUP98 protein fragments expressed in E.coli. |
| Conjugation | Un-conjugated |
| Alternate Names | NUP196; Nuclear pore complex protein Nup98-Nup96; ADIR2; Nup98; Nup96; NUP96; 98 kDa nucleoporin; Nucleoporin Nup98; Nucleoporin Nup96; 96 kDa nucleoporin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 98 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.1M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% Sodium azide and 50% Glycerol |
| Preservative | 0.2% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P52948 Human Nuclear pore complex protein Nup98-Nup96 |
|---|---|
| Gene Symbol | NUP98 |
| Gene Full Name | nucleoporin 98kDa |
| Background | Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. |
| Function | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. [UniProt] |
| Cellular Localization | Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. |
| Research Area | Gene Regulation antibody; Signaling Transduction antibody |
| Calculated MW | 198 kDa |
| PTM | Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively (PubMed:10087256, PubMed:20407419, PubMed:12191480, PubMed:18287282). Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96 (PubMed:20407419, PubMed:12191480). Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation. |
Images (2) Click the Picture to Zoom In
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ARG54088 anti-NUP98 antibody WB image
Western blot: HeLa cell lysate stained with ARG54088 anti-NUP98 antibody at 1:1000 dilution.
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ARG54088 anti-NUP98 antibody IP image
Immunoprecipitation: HeLa cell lysates were immunoprecipitated and stained with ARG54088 anti-NUP98 antibody.
