ARG45824
anti-Nebulette antibody
anti-Nebulette antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Nebulette |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Nebulette |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human Nebulette. |
| Conjugation | Un-conjugated |
| Alternate Names | NEBL; Nebulette; LNEBL; BA165O3.1; C10orf113; LASP2; Actin-Binding Z-Disk Protein; LIM And SH3 Protein 2; LIM-Nebulette; Chromosome 10 Open Reading Frame 113 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 126 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O76041 Human Nebulette Swiss-port # Q9DC07 Mouse LIM zinc-binding domain-containing Nebulette |
|---|---|
| Gene Symbol | NEBL |
| Gene Full Name | Nebulette |
| Background | This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
| Function | Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 126 kDa |
| PTM | Methylation. [UniProt] |
