ARG43794
anti-Nkx 6.1 antibody
anti-Nkx 6.1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Nkx 6.1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Nkx 6.1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to N-terminal of Human Nkx 6.1. |
| Conjugation | Un-conjugated |
| Protein Full Name | Homeobox protein Nkx-6.1 |
| Alternate Names | NKX6-1 NK6 homeobox 1; Nkx6.1; NKX6A; Homeobox Protein NK-6 Homolog A; Homeobox Protein Nkx-6.1; Nkx6.1; NK6 Transcription Factor Related, Locus 1 (Drosophila); NK6 Transcription Factor Related, Locus 1; NK Homeobox (Drosophila), Family 6, A; NK6 Transcription Factor Homolog A; NK Homeo Box, Family 6, Member A; NK Homeobox, Family 6, A; NKX6.1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | BxPC3; mouse pancreas |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.05% Proclin300 and 50% Glycerol. |
| Preservative | 0.05% Proclin300 |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | NKX6-1 |
| Gene Full Name | NK6 homeobox 1 |
| Background | The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008] |
| Function | Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity). [UniProt] |
| Cellular Localization | Nuclear |
| Calculated MW | 30 kDa |
Images (1) Click the Picture to Zoom In
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ARG43794 anti-Nkx 6.1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded mouse pancreas tissue stained with ARG43794 anti-Nkx 6.1 antibody.
