Overview

Product Description	Rabbit Polyclonal antibody recognizes Nur77 / TR3
Tested Reactivity	Hu, Ms, Rat
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	Nur77 / TR3
Antigen Species	Human
Immunogen	Synthetic peptide derived from Human Nur77 / TR3.
Conjugation	Un-conjugated
Alternate Names	ST-59; N10; Nur77; GFRP1; Testicular receptor 3; NP10; NAK-1; HMR; Orphan nuclear receptor TR3; Nuclear hormone receptor NUR/77; Orphan nuclear receptor HMR; Early response protein NAK1; NGFIB; TR3; NUR77; Nuclear receptor subfamily 4 group A member 1

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 15370 Mouse NR4A1 GeneID: 3164 Human NR4A1 GeneID: 79240 Rat NR4A1 Swiss-port # P12813 Mouse Nuclear receptor subfamily 4 group A member 1 Swiss-port # P22736 Human Nuclear receptor subfamily 4 group A member 1 Swiss-port # P22829 Rat Nuclear receptor subfamily 4 group A member 1 More
Gene Symbol	NR4A1
Gene Full Name	nuclear receptor subfamily 4, group A, member 1
Background	This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Function	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. [UniProt]
Cellular Localization	Cytoplasm. Nucleus. [UniProt]
Calculated MW	64 kDa
PTM	Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1. [UniProt]

Images (1) Click the Picture to Zoom In