ARG45313
anti-OCRL antibody
anti-OCRL antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Polyclonal antibody recognizes OCRL |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Target Name | OCRL |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human OCRL. |
| Conjugation | Un-conjugated |
| Alternate Names | OCRL; OCRL Inositol Polyphosphate-5-Phosphatase; OCRL1; Dent-2; Phosphatidylinositol 3,4,5-Triphosphate 5-Phosphatase; Inositol Polyphosphate 5-Phosphatase OCRL-1; Inositol Polyphosphate 5-Phosphatase OCRL; Lowe Oculocerebrorenal Syndrome Protein; Oculocerebrorenal Syndrome Of Lowe; OCRL-1; Phosphatidylinositol Polyphosphate 5-Phosphatase; Dent Disease 2; EC 3.1.3.36; EC 3.1.3.56; EC 3.1.3.86; INPP5F; DENT2; NPHL2; LOCR |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 104 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q01968 Human Inositol polyphosphate 5-phosphatase OCRL-1 |
|---|---|
| Gene Symbol | OCRL |
| Gene Full Name | OCRL Inositol Polyphosphate-5-Phosphatase |
| Background | This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] GeneCards Summary for OCRL Gene |
| Function | Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 . [UniProt] |
| Cellular Localization | Cell projection; Cilium; Coated pit; Cytoplasmic vesicle; Endosome; Golgi apparatus; Lysosome; Membrane. [UniProt] |
| Calculated MW | 104 kDa |
