ARG45949
anti-PNKP / PNK antibody
anti-PNKP / PNK antibody for Flow cytometry,ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PNKP / PNK |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PNKP / PNK |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human PNKP / PNK. |
| Conjugation | Un-conjugated |
| Alternate Names | PNKP; Polynucleotide Kinase 3'-Phosphatase; Polynucleotide kinase-3'-phosphatase; MCSZ; EIEE10; PNK; 2'; Bifunctional polynucleotide phosphatase/kinase; EC 3.1.3.32; EC 2.7.1.78; AOA4; 3'; DNA 5'-kinase/3'-phosphatase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 57 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -22°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q96T60 Human Bifunctional polynucleotide phosphatase/kinase |
|---|---|
| Gene Symbol | PNKP |
| Gene Full Name | Polynucleotide Kinase 3'-Phosphatase |
| Background | This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010] |
| Function | Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. [UniProt] |
| Cellular Localization | Nucleus; Chromosome. [UniProt] |
| Calculated MW | 57 kDa |
| PTM | Phosphoprotein; Acetylation. [UniProt]. [UniProt] |
