ARG45590
anti-PPM1E antibody
anti-PPM1E antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PPM1E |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PPM1E |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human PPM1E. |
| Conjugation | Un-conjugated |
| Alternate Names | PPM1E; Protein Phosphatase, Mg2+/Mn2+ Dependent 1E; CaMKP-N; POPX1; Partner Of PIX 1; KIAA1072; PP2CH; Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase N; Nuclear Calmodulin-Dependent Protein Kinase Phosphatase; Protein Phosphatase 1E (PP2C Domain Containing); Protein Phosphatase 1E; Partner Of PIX-Alpha; Partner Of PIXA; CaMKP-Nucleus; CaMKN; Protein Phosphatase, Mg2+/Mn2+ Dependent, 1E; EC 3.1.3.16; CAMKPN; CAMKN |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 84 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PPM1E |
| Gene Full Name | Protein Phosphatase, Mg2+/Mn2+ Dependent 1E |
| Background | This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
| Function | Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2. [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 84 kDa |
| PTM | Phosphoprotein. [UniProt] |
