ARG45805
anti-PRAGMIN / SGK223 antibody
anti-PRAGMIN / SGK223 antibody for Flow cytometry,ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PRAGMIN / SGK223 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PRAGMIN / SGK223 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human PRAGMIN / SGK223. |
| Conjugation | Un-conjugated |
| Alternate Names | PRAG1; PEAK1 Related, Kinase-Activating Pseudokinase 1; SgK223; Sugen Kinase 223; PRAGMIN; PEAK2; NACK; Inactive Tyrosine-Protein Kinase PRAG1; Pragmin, RND2 Effector Protein; PEAK Family Member 2; DKFZp761P0423; PEAK1-Related Kinase-Activating Pseudokinase 1; Tyrosine-Protein Kinase SgK223; Homolog Of Rat Pragma Of Rnd2; Tyrosine-Protein Kinase PRAG1; Pragmin; SGK223 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 200 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PRAG1 |
| Gene Full Name | PEAK1 Related, Kinase-Activating Pseudokinase 1 |
| Background | This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014] |
| Function | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). [UniProt] |
| Cellular Localization | Cell junction; Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 150 kDa |
| PTM | Phosphoprotein. [UniProt] |
