Overview

Product Description	Rabbit Polyclonal antibody recognizes QPCT
Tested Reactivity	Hu, Ms, Rat
Tested Application	ICC/IF, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	QPCT
Antigen Species	Human
Immunogen	Recombinant fusion protein corresponding to aa. 1-361 of Human QPCT (NP_036545.1).
Conjugation	Un-conjugated
Alternate Names	EC 2.3.2.5; Glutaminyl cyclase; Glutamyl cyclase; EC; QC; Glutaminyl-peptide cyclotransferase; GCT; sQC; Glutaminyl-tRNA cyclotransferase

Application Instructions

Application Suggestion	Tested Application Dilution ICC/IF 1:50 - 1:200 WB 1:1000 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 25797 Human QPCT GeneID: 70536 Mouse QPCT Swiss-port # Q16769 Human Glutaminyl-peptide cyclotransferase Swiss-port # Q9CYK2 Mouse Glutaminyl-peptide cyclotransferase
Gene Symbol	QPCT
Gene Full Name	glutaminyl-peptide cyclotransferase
Background	This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Function	Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. [UniProt]
Cellular Localization	Secreted. [UniProt]
Calculated MW	41 kDa

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