Overview

Product Description	Rabbit Polyclonal antibody recognizes RERE
Tested Reactivity	Hu, Ms, Rat
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	RERE
Antigen Species	Human
Immunogen	Recombinant fusion protein corresponding to aa. 1-220 of Human RERE (NP_036234.3).
Conjugation	Un-conjugated
Alternate Names	ARP; Arginine-glutamic acid dipeptide repeats protein; Atrophin-1-related protein; Atrophin-1-like protein; ARG; ATN1L; DNB1

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	Jurkat
Observed Size	172 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 116665 Rat RERE GeneID: 473 Human RERE GeneID: 68703 Mouse RERE Swiss-port # Q62901 Rat Arginine-glutamic acid dipeptide repeats protein Swiss-port # Q80TZ9 Mouse Arginine-glutamic acid dipeptide repeats protein Swiss-port # Q9P2R6 Human Arginine-glutamic acid dipeptide repeats protein More
Gene Symbol	RERE
Gene Full Name	arginine-glutamic acid dipeptide (RE) repeats
Background	This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function	Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. [UniProt]
Cellular Localization	Nucleus. [UniProt]
Calculated MW	172 kDa

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