Overview

Product Description	Mouse Monoclonal antibody recognizes RNF135
Tested Reactivity	Hu
Tested Application	WB
Host	Mouse
Clonality	Monoclonal
Isotype	IgG1
Target Name	RNF135
Antigen Species	Human
Epitope	HLRKNTLLQD LADKYRRAAR EIQAGSDPAH CPCPGSSSLS SAAARPRRRP ELQRVAVEKS ITEVAQELTE LVEHLVDIVR SLQNQRPLSE SGPDNELSIL GKAFSSGVDL SMASPKLVTS DTAAGKIRDI LHDLEEIQEK LQESVTWKEA PEAQMQGELL
Conjugation	Un-conjugated
Alternate Names	RNF135; Ring Finger Protein 135; Riplet; RING Finger Protein Leading To RIG-I Activation; RING-Type E3 Ubiquitin Transferase RNF135; E3 Ubiquitin-Protein Ligase RNF135; RIG-I E3 Ubiquitin Ligase; MGC13061; REUL; RING Finger Protein 135; EC 2.3.2.27; MMFD; L13

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:1000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Protein A purification
Buffer	PBS with 0.09% sodium azide
Preservative	0.09% sodium azide
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 84282 Human RNF135 Swiss-port # Q8IUD6 Human E3 ubiquitin-protein ligase RNF135
Gene Symbol	RNF135
Gene Full Name	Ring Finger Protein 135
Background	The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Function	This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway. [UniProt]
Cellular Localization	Cytoplasm
Calculated MW	48 kDa

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