ARG59141
anti-RRM2 antibody
anti-RRM2 antibody for ICC/IF,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RRM2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RRM2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human RRM2. |
| Conjugation | Un-conjugated |
| Alternate Names | R2; EC 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; RR2M; RR2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | ~ 45 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P31350 Human Ribonucleoside-diphosphate reductase subunit M2 |
|---|---|
| Gene Symbol | RRM2 |
| Gene Full Name | ribonucleotide reductase M2 |
| Background | This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] |
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 45 kDa |
| PTM | Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG59141 anti-RRM2 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG59141 anti-RRM2 antibody at 1:100 dilution (red). DAPI nuclear staining (blue)
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ARG59141 anti-RRM2 antibody WB image
Western blot: HeLa cell lysate stained with ARG59141 anti-RRM2 antibody.
