ARG67242
anti-RUNX2 antibody
anti-RUNX2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody recognizes RUNX2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | RUNX2 |
| Conjugation | Un-conjugated |
| Alternate Names | RUNX2; RUNX Family Transcription Factor 2; AML3; Runt-Related Transcription Factor 2; CBFA1; Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit; SL3/AKV Core-Binding Factor Alpha A Subunit; Osteoblast-Specific Transcription Factor 2; SL3-3 Enhancer Factor 1 Alpha A Subunit; Runt Related Transcription Factor 2; Acute Myeloid Leukemia 3 Protein; Oncogene AML-3; PEBP2-Alpha A; PEA2-Alpha A; CBF-Alpha-1; PEBP2aA1; PEBP2A1; OSF-2; CCD1; OSF2; CCD; Core-Binding Factor, Runt Domain, Alpha Subunit 1; Core-Binding Factor Subunit Alpha-1; PEBP2aA; PEA2aA; PEBP2A; CLCD |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | PBS (pH 7.0), 0.025% ProClin 300 and 20% Glycerol. |
| Preservative | 0.025% ProClin 300 |
| Stabilizer | 20% Glycerol |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q08775 Mouse Runt-related transcription factor 2 Swiss-port # Q13950 Human Runt-related transcription factor 2 |
|---|---|
| Gene Symbol | RUNX2 |
| Gene Full Name | RUNX Family Transcription Factor 2 |
| Background | This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016] |
| Function | Inhibits KAT6B-dependent transcriptional activation. [Uniprot] |
| Cellular Localization | Cytoplasm, Nucleus. [Uniprot] |
| Calculated MW | 57 kDa |
| PTM | Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation. [Uniprot] |
