ARG45774
anti-Riz1 antibody
anti-Riz1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Riz1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Riz1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human Riz1. |
| Conjugation | Un-conjugated |
| Alternate Names | PRDM2; PR/SET Domain 2; MTB-ZF; KMT8; RIZ; Retinoblastoma Protein-Interacting Zinc Finger Protein; MTE-Binding Protein; HUMHOXY1; KMT8A; RIZ1; RIZ2; Retinoblastoma Protein-Binding Zinc Finger Protein; PR Domain Containing 2, With ZNF Domain; Zinc-Finger DNA-Binding Protein; PR Domain Zinc Finger Protein 2; PR Domain-Containing Protein 2; Lysine N-Methyltransferase 8; GATA-3 Binding Protein G3B; Zinc Finger Protein RIZ; PR Domain 2; GATA-3-Binding Protein G3B; EC 2.1.1.355 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 280 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PRDM2 |
| Gene Full Name | PR/SET Domain 2 |
| Background | This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| Function | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. . [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 189 kDa |
| PTM | Isopeptide bond; Phosphoprotein; Ubl conjugation. [UniProt] |
