Overview

Product Description	Rabbit Polyclonal antibody recognizes SAMHD1
Tested Reactivity	Hu
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	SAMHD1
Antigen Species	Human
Immunogen	Synthetic peptide derived from Human SAMHD1.
Conjugation	Un-conjugated
Alternate Names	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; EC 3.1.5.-; SBBI88; SAM domain and HD domain-containing protein 1; HDDC1; MOP-5; DCIP; CHBL2; dNTPase; Dendritic cell-derived IFNG-induced protein; Monocyte protein 5

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:1000 - 1:5000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size	72kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 25939 Human SAMHD1 Swiss-port # Q9Y3Z3 Human Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Gene Symbol	SAMHD1
Gene Full Name	SAM domain and HD domain 1
Background	This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]
Function	Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. [UniProt]
Cellular Localization	Nucleus. [UniProt]
Calculated MW	72 kDa
PTM	Ubiquitinated and targeted for proteasomal degradation by a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase with the help of the viral accessory protein Vpx. [UniProt]

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