Overview

Product Description	Rabbit Polyclonal antibody recognizes SFRP4
Tested Reactivity	Hu, Ms, Rat
Tested Application	FACS, ICC/IF, IHC-P, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	SFRP4
Antigen Species	Human
Immunogen	Synthetic peptide derived from Human SFRP4.
Conjugation	Un-conjugated
Alternate Names	Frizzled protein, human endometrium; FRP-4; FRPHE; Secreted frizzled-related protein 4; FrpHE; sFRP-4

Application Instructions

Application Suggestion	Tested Application Dilution FACS 1:50 ICC/IF 1:50 - 1:200 IHC-P 1:50 - 1:200 WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	293T
Observed Size	~ 51 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 20379 Mouse SFRP4 GeneID: 6424 Human SFRP4 GeneID: 89803 Rat SFRP4 Swiss-port # Q6FHJ7 Human Secreted frizzled-related protein 4 Swiss-port # Q9JLS4 Rat Secreted frizzled-related protein 4 Swiss-port # Q9Z1N6 Mouse Secreted frizzled-related sequence protein 4 More
Gene Symbol	SFRP4
Gene Full Name	secreted frizzled-related protein 4
Background	Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
Function	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927). [UniProt]
Cellular Localization	Secreted. Note=Cytoplasmic in ovarian tumor cells. [UniProt]
Calculated MW	40 kDa

Images (1) Click the Picture to Zoom In