ARG45271
anti-SGO2 antibody
anti-SGO2 antibody for Flow cytometry,ICC/IF,Western blot and Human
Overview
| Product Description | Polyclonal antibody recognizes SGO2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SGO2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human SGO2. |
| Conjugation | Un-conjugated |
| Alternate Names | SGO2; Shugoshin 2; TRIPIN; SGOL2; Shugoshin-Like 2; FLJ25211; Shugoshin-Like 2 (S. Pombe); Shugoshin-2; Tripin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 180 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SGO2 |
| Gene Full Name | Shugoshin 2 |
| Background | Predicted to be involved in meiotic sister chromatid cohesion. Predicted to act upstream of or within several processes, including meiotic nuclear division; meiotic sister chromatid cohesion; and positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesin complex. [provided by Alliance of Genome Resources, Nov 2024] |
| Function | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation . [UniProt] |
| Cellular Localization | Cellular component; Centromere; Chromosome; Kinetochore; Nucleus. [UniProt] |
| Calculated MW | 145 kDa |
| PTM | Phosphoprotein. [UniProt] |
