ARG45171
anti-SLC18A1 / VMAT1 antibody
anti-SLC18A1 / VMAT1 antibody for Flow cytometry,Immunohistochemistry,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SLC18A1 / VMAT1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SLC18A1 / VMAT1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human SLC18A1 / VMAT1 . |
| Conjugation | Un-conjugated |
| Alternate Names | SLC18A1; solute carrier family 18 member A1; Chromaffin granule amine transporter; Solute carrier family 18 member 1; Vesicular amine transporter 1; VAT1; SLC18A1; VAT1; VMAT1 |
Application Instructions
| Application Suggestion |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 56 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P54219 Human Chromaffin granule amine transporter |
|---|---|
| Gene Symbol | SLC18A1 |
| Gene Full Name | solute carrier family 18 member A1 |
| Background | The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008] |
| Function | Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin. [UniProt] |
| Cellular Localization | Cytoplasmic vesicle membrane; Synaptic vesicle membrane; Endoplasmic reticulum membrane. [UniProt] |
| Calculated MW | 56 kDa |
| PTM | Glycoprotein. [UniProt] |
