ARG45278
anti-SPDEF / PSE antibody
anti-SPDEF / PSE antibody for Flow cytometry,ICC/IF,Western blot and Human
Overview
| Product Description | Polyclonal antibody recognizes SPDEF / PSE |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SPDEF / PSE |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human SPDEF / PSE. |
| Conjugation | Un-conjugated |
| Alternate Names | SPDEF; SAM Pointed Domain Containing ETS Transcription Factor; PDEF; BA375E1.3; SAM Pointed Domain-Containing Ets Transcription Factor; Prostate Epithelium-Specific Ets Transcription Factor; Prostate-Derived Ets Factor; Prostate-Specific Ets; PSE |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 44 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O95238 Human SAM pointed domain-containing Ets transcription factor |
|---|---|
| Gene Symbol | SPDEF / PSE |
| Gene Full Name | SAM Pointed Domain Containing ETS Transcription Factor |
| Background | The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| Function | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 38 kDa |
