ARG45726
anti-SPG3A / ATL1 antibody
anti-SPG3A / ATL1 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SPG3A / ATL1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SPG3A / ATL1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to middle region of human SPG3A / ATL1. |
| Conjugation | Un-conjugated |
| Alternate Names | ATL1; Atlastin GTPase 1; AD-FSP; SPG3A; FSP1; Guanine Nucleotide-Binding Protein 3; Brain-Specific GTP-Binding Protein; Spastic Paraplegia 3 Protein A; GTP-Binding Protein 3; Atlastin-1; GBP-3; HGBP3; GBP3; SPG3; Spastic Paraplegia 3A (Autosomal Dominant); Guanylate-Binding Protein 3; EC 3.6.5.-; Atlastin1; Atlastin; HSN1D |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 64 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ATL1 |
| Gene Full Name | Atlastin GTPase 1 |
| Background | The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. [UniProt] |
| Cellular Localization | Cell projection; Endoplasmic reticulum; Golgi apparatus; Membrane. [UniProt] |
| Calculated MW | 64 kDa |
| PTM | Acetylation; Phosphoprotein. [UniProt] |
