ARG45733
anti-SPTBN2 antibody
anti-SPTBN2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SPTBN2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SPTBN2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human SPTBN2. |
| Conjugation | Un-conjugated |
| Alternate Names | SPTBN2; Spectrin Beta, Non-Erythrocytic 2; SCA5; Spectrin Beta Chain, Non-Erythrocytic 2; Spinocerebellar Ataxia 5 Protein; Beta-III Spectrin; Glutamate Transporter EAAT4-Associated Protein 41; Spectrin, Non-Erythroid Beta Chain 2; Spectrin Beta Chain, Brain 2; Spectrin Beta III Sigma 2; Spinocerebellar Ataxia 5; KIAA0302; GTRAP41; SCAR14 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 271 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O15020 Human Spectrin beta chain, non-erythrocytic 2 Swiss-port # Q9QWN8 Rat Spectrin beta chain, non-erythrocytic 2 |
|---|---|
| Gene Symbol | SPTBN2 |
| Gene Full Name | Spectrin Beta, Non-Erythrocytic 2 |
| Background | Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009] |
| Function | Probably plays an important role in neuronal membrane skeleton. . [UniProt] |
| Cellular Localization | Cytoplasm; Cytoskeleton. [UniProt] |
| Calculated MW | 271 kDa |
| PTM | Acetylation; Phosphoprotein. [UniProt] |
