ARG45908
anti-Skeletrophin / Mib2 antibody
anti-Skeletrophin / Mib2 antibody for Western blot,Immunoprecipitation,Flow cytometry and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Skeletrophin / Mib2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Skeletrophin / Mib2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human Skeletrophin / Mib2. |
| Conjugation | Un-conjugated |
| Alternate Names | MIB E3 Ubiquitin Protein Ligase 2; MIB2; SKD; ZZANK1; E3 ubiquitin-protein ligase MIB2; EC 2.3.2.27; Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 110 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -22°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MIB2 |
| Gene Full Name | MIB E3 Ubiquitin Protein Ligase 2 |
| Background | The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017] |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. [UniProt] |
| Cellular Localization | Cytoplasm; Endosome. [UniProt] |
| Calculated MW | 110 kDa |
| PTM | Acetylation; Phosphoprotein; Ubl conjugation. [UniProt] |
