ARG55242
anti-Slug antibody
anti-Slug antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cancer antibody; Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody
Publication1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Slug |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Predict Reactivity | Bov |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Slug |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 98-129 (Center) of Human Slug. |
| Conjugation | Un-conjugated |
| Alternate Names | Protein snail homolog 2; SNAIL2; WS2D; Neural crest transcription factor Slug; Zinc finger protein SNAI2; SLUG; SLUGH1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Mouse heart |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SNAI2 |
| Gene Full Name | snail family zinc finger 2 |
| Background | SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects. |
| Research Area | Cancer antibody; Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody |
| Calculated MW | 30 kDa |
| PTM | GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation. |
Images (3) Click the Picture to Zoom In
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ARG55242 anti-Slug antibody ICC/IF image
Immunofluorescence: HepG2 cells stained with ARG55242 anti-Slug antibody (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI (blue) for nuclear staining.
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ARG55242 anti-Slug antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human Breast tissue stained with ARG55242 anti-Slug antibody.
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ARG55242 anti-Slug antibody WB image
Western blot: 20 µg of Mouse heart lysate stained with ARG55242 anti-Slug antibody at 1:2000 dilution.
Specific References
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
WB / Human
