ARG62633
anti-Syntaxin antibody [STX01 (HPC-1)]
anti-Syntaxin antibody [STX01 (HPC-1)] for ICC/IF,Immunoprecipitation,Western blot and Human,Rat
Cancer antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [STX01 (HPC-1)] recognizes Syntaxin |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | ICC/IF, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | STX01 (HPC-1) |
| Isotype | IgG1 |
| Target Name | Syntaxin |
| Antigen Species | Rat |
| Immunogen | amino acids 3-225- raised against Syntaxin 1 of rat origin |
| Conjugation | Un-conjugated |
| Alternate Names | HPC-1; STX1; Syntaxin-1A; SYN1A; Neuron-specific antigen HPC-1; P35-1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | SH-SY5Y cell lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified Antibody |
| Buffer | 1X PBS and 0.1% Sodium azide |
| Preservative | 0.1% Sodium azide |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Stx1a |
| Gene Full Name | syntaxin 1A (brain) |
| Background | This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| Function | Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [UniProt] |
| Research Area | Cancer antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| Calculated MW | 33 kDa |
| PTM | Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1. |
Clone References
Amacrine cell subtypes differ in their intrinsic neurite growth capacity.
IHC / Rat
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.
VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex.
IHC-P / Rat
Foxn4 is required for retinal ganglion cell distal axon patterning.
IHC / Mouse
Amacrine cell gene expression and survival signaling: differences from neighboring retinal ganglion cells.
ICC/IF / Rat
