ARG54729
anti-TAB3 antibody
anti-TAB3 antibody for Western blot and Human
Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TAB3 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TAB3 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 1-30 (N-terminus) of Human TAB3 (NP_690000.3). |
| Conjugation | Un-conjugated |
| Alternate Names | TAB-3; MAP3K7IP3; NAP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-binding protein 3; TAK1-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Protein A purified |
|---|---|
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8N5C8 Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
|---|---|
| Gene Symbol | TAB3 |
| Gene Full Name | TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
| Background | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| Function | Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. [From Uniprot] |
| Highlight | Related products: Anti-Rabbit IgG secondary antibodies; Related poster download: The NF-kappa B Pathways.pdf |
| Research Area | Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody |
| Calculated MW | 79 kDa |
| PTM | Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. |
Images (1) Click the Picture to Zoom In
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ARG54729 anti-TAB3 antibody WB image
Western blot: 30 µg of 1) HeLa without treatment, 2-4) HeLa treated with 5 ng/ml TNF-a for 5, 10 and 20 min, respectively. Cell lysates stained with ARG54729 anti-TAB3 antibody at 1:500 dilution.
