ARG43437
anti-TCIRG1 antibody
anti-TCIRG1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Publication1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TCIRG1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TCIRG1 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-130 of Human TCIRG1 (NP_006010.2). |
| Conjugation | Un-conjugated |
| Alternate Names | V-ATPase 116 kDa isoform a3; Stv1; V-type proton ATPase 116 kDa subunit a isoform 3; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3; ATP6V0A3; OC-116 kDa; ATP6N1C; Vph1; T-cell immune regulator 1; a3; OC116; OPTB1; Atp6i; OC-116kDa; T-cell immune response cDNA7 protein; TIRC7; Osteoclastic proton pump 116 kDa subunit |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q13488 Human V-type proton ATPase 116 kDa subunit a isoform 3 |
|---|---|
| Gene Symbol | TCIRG1 |
| Gene Full Name | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 |
| Background | This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017] |
| Function | Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. [UniProt] |
| Cellular Localization | Membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 93 kDa |
Images (2) Click the Picture to Zoom In
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ARG43437 anti-TCIRG1 antibody ICC/IF image
Immunofluorescence: L929 cells stained with ARG43437 anti-TCIRG1 antibody at 1:100 dilution.
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ARG43437 anti-TCIRG1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver tissue stained with ARG43437 anti-TCIRG1 antibody at 1:100 dilution.
Specific References
Histochemical assessment of osteoclast-like giant cells in Rankl-/- mice
IHC-P / Mouse
