ARG45474
anti-THEM4 antibody
anti-THEM4 antibody for Flow cytometry,ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes THEM4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | THEM4 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human THEM4. |
| Conjugation | Un-conjugated |
| Alternate Names | THEM4; Thioesterase Superfamily Member 4; CTMP; Carboxyl-Terminal Modulator Protein; Acyl-Coenzyme A Thioesterase THEM4; C-Terminal Modulator Protein; Acyl-CoA Thioesterase THEM4; EC 3.1.2.2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 22 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q5T1C6 Human Acyl-coenzyme A thioesterase THEM4 |
|---|---|
| Gene Symbol | THEM4 |
| Gene Full Name | Thioesterase Superfamily Member 4 |
| Background | Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008] |
| Function | Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. [UniProt] |
| Cellular Localization | Cell membrane; Cell projection; Cytoplasm; Membrane; Mitochondrion; Mitochondrion inner membrane. [UniProt] |
| Calculated MW | 27 kDa |
