ARG67271
anti-TIA1 antibody [SQab30387]
anti-TIA1 antibody [SQab30387] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Monoclonal antibody [SQab30387] recognizes TIA1. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30387 |
| Isotype | IgG |
| Target Name | TIA1 |
| Immunogen | Synthetic peptide. |
| Conjugation | Un-conjugated |
| Alternate Names | TIA1; TIA1 Cytotoxic Granule Associated RNA Binding Protein; TIA-1; T-Cell-Restricted Intracellular Antigen-1; Cytotoxic Granule Associated RNA Binding Protein TIA1; Nucleolysin TIA-1 Isoform P40; TIA1 Cytotoxic Granule-Associated RNA-Binding Protein; P40-TIA-1 (Containing P15-TIA-1); RNA-Binding Protein TIA-1; P40-TIA-1; ALS26; WDM |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | P31483 |
| Gene Full Name | TIA1 |
| Background | The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017] |
| Function | Possesses nucleolytic activity against cytotoxic lymphocyte target cells. [Uniprot] |
| Cellular Localization | Cytoplasm, Nucleus. [Uniprot] |
| Calculated MW | 43 kDa |
| PTM | Acetylation. [Uniprot] |
