ARG67087
anti-TIGIT antibody [SQab30360]
anti-TIGIT antibody [SQab30360] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant Rabbit Monoclonal antibody [SQab30360] recognizes TIGIT |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30360 |
| Isotype | IgG |
| Target Name | TIGIT |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human TIGIT. |
| Conjugation | Un-conjugated |
| Alternate Names | TIGIT; T Cell Immunoreceptor With Ig And ITIM Domains; VSIG9; VSTM3; V-Set And Immunoglobulin Domain-Containing Protein 9; V-Set And Transmembrane Domain-Containing Protein 3; T-Cell Immunoreceptor With Ig And ITIM Domains; DKFZp667A205; VSIG9, VSTM3; FLJ39873; V-Set And Immunoglobulin Domain Containing 9; Washington University Cell Adhesion Molecule 3; V-Set And Transmembrane Domain Containing 3; WUCAM |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q495A1 Human T-cell immunoreceptor with Ig and ITIM domains |
|---|---|
| Gene Symbol | TIGIT |
| Gene Full Name | T Cell Immunoreceptor With Ig And ITIM Domains |
| Background | This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. |
| Function | Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
| Cellular Localization | Cell membrane, Membrane |
| Calculated MW | 26 kDa |
| PTM | Disulfide bond, Glycoprotein |
Images (1) Click the Picture to Zoom In
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ARG67087 anti-TIGIT antibody [SQab30360] IHC-P image
Immunohistochemistry: Human tonsil stained with ARG67087 anti-TIGIT antibody [SQab30360]
