ARG56104
anti-TNFRSF18 antibody [DTA-1]
anti-TNFRSF18 antibody [DTA-1] for Flow cytometry,ICC/IF and Mouse
Overview
| Product Description | Rat Monoclonal antibody [DTA-1] recognizes TNFRSF18 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | FACS, ICC/IF |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | DTA-1 |
| Isotype | IgG2b, lambda |
| Target Name | TNFRSF18 |
| Antigen Species | Mouse |
| Immunogen | Mouse CD25+ CD4+ T cells. |
| Conjugation | Un-conjugated |
| Alternate Names | AITR; CD antigen CD357; Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; Gitr |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 0.1 mg/ml BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O35714 Mouse Tumor necrosis factor receptor superfamily member 18 |
|---|---|
| Gene Symbol | Tnfrsf18 |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 18 |
| Background | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
| Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity). [UniProt] |
| Cellular Localization | Secreted, cell surface |
| Calculated MW | 26 kDa |
