Overview

Product Description	Rabbit Polyclonal antibody recognizes TRAM2
Tested Reactivity	Hu, Ms, Rat
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	TRAM2
Antigen Species	Human
Immunogen	Synthetic peptide derived from Human TRAM2.
Conjugation	Un-conjugated
Alternate Names	Translocating chain-associated membrane protein 2

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size	~ 40 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 170829 Mouse TRAM2 GeneID: 9697 Human TRAM2 Swiss-port # Q15035 Human Translocating chain-associated membrane protein 2 Swiss-port # Q924Z5 Mouse Translocating chain-associated membrane protein 2
Gene Symbol	TRAM2
Gene Full Name	translocation associated membrane protein 2
Background	TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
Function	Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. [UniProt]
Cellular Localization	Membrane; Multi-pass membrane protein. [UniProt]
Calculated MW	43 kDa

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