ARG65598
anti-TRPC3 antibody
anti-TRPC3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cell Biology and Cellular Response antibody; Neuroscience antibody; Signaling Transduction antibody
Publication2
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TRPC3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TRPC3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of human TRPC3 |
| Conjugation | Un-conjugated |
| Alternate Names | hTrp3; hTrp-3; TrpC3; Transient receptor protein 3; TRP3; SCA41; Short transient receptor potential channel 3; TRP-3 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified by antigen-affinity chromatography. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide, 0.5% BSA and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA and 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q13507 Human Short transient receptor potential channel 3 |
|---|---|
| Gene Symbol | TRPC3 |
| Gene Full Name | transient receptor potential cation channel, subfamily C, member 3 |
| Background | The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. |
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. [UniProt] |
| Research Area | Cell Biology and Cellular Response antibody; Neuroscience antibody; Signaling Transduction antibody |
| Calculated MW | 96 kDa |
Images (3) Click the Picture to Zoom In
-
ARG65598 anti-TRPC3 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human ovarian cancer tissue stained with ARG65598 anti-TRPC3 antibody (left) at 1:80 dilution, or the same antibody preincubated with synthetic peptide (right). (Original magnification: ×200).
-
ARG65598 anti-TRPC3 antibody WB image
Western blot: 40 μg of Human fetal brain lysate stained with ARG65598 anti-TRPC3 antibody at 1:1600 dilution. Exposure time: 2 minutes.
-
ARG65598 anti-TRPC3 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG65598 anti-TRPC3 antibody (left) at 1:80 dilution, or the same antibody preincubated with synthetic peptide (right). (Original magnification: ×200).
Specific References
Brain-derived neurotrophic factor plays a neuroprotective role by up-regulating TRPC3 expression in a mouse model of amyloid β-protein-induced Alzheimer disease.
WB / Mouse
β-淀粉样蛋白诱导的阿尔茨海默病大鼠模型中BDNF与TRPC3的关系
WB / Rat
