ARG45445
anti-UBA6 antibody
anti-UBA6 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,Flow cytometry and Human,Monkey,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes UBA6 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Mk |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | UBA6 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human UBA6. |
| Conjugation | Un-conjugated |
| Alternate Names | UBA6; Ubiquitin Like Modifier Activating Enzyme 6; UBE1L2; Ubiquitin-Activating Enzyme E1-Like Protein 2; Ubiquitin-Like Modifier-Activating Enzyme 6; Ubiquitin-Activating Enzyme E1-Like 2; UBA6, Ubiquitin-Activating Enzyme E1; Ubiquitin-Activating Enzyme 6; Monocyte Protein 4; FLJ10808; E1-L2; MOP-4; Ubiquitin-Like Modifier Activating Enzyme 6; EC 6.2.1.45; MOP4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 118 kDa |
Properties
| Form | Powder |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # A0AVT1 Human Ubiquitin-like modifier-activating enzyme 6 Swiss-port # Q8C7R4 Mouse Ubiquitin-like modifier-activating enzyme 6 |
|---|---|
| Gene Symbol | UBA6 |
| Gene Full Name | Ubiquitin Like Modifier Activating Enzyme 6 |
| Background | Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008] |
| Function | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 118 kDa |
| PTM | Acetylation; Phosphoprotein. [UniProt] |
