ARG41409
anti-VLDL Receptor antibody [VLDLR/1337]
anti-VLDL Receptor antibody [VLDLR/1337] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [VLDLR/1337] recognizes VLDL Receptor |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | VLDLR/1337 |
| Isotype | IgG1, kappa |
| Target Name | VLDL Receptor |
| Antigen Species | Human |
| Immunogen | Recombinant partial protein around the C-terminal region of Human VLDL Receptor. |
| Conjugation | Un-conjugated |
| Alternate Names | VLDLRCH; VLDL-R; VLDL receptor; CARMQ1; Very low-density lipoprotein receptor; CAMRQ1; CHRMQ1 |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Tris with 1 mM EDTA (pH 9.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 0.1 mg/ml BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P98155 Human Very low-density lipoprotein receptor |
|---|---|
| Gene Symbol | VLDLR |
| Gene Full Name | very low density lipoprotein receptor |
| Background | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009] |
| Function | Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 96 kDa |
| PTM | Ubiquitinated at Lys-839 by MYLIP leading to degradation. [UniProt] |
Images (1) Click the Picture to Zoom In
-
ARG41409 anti-VLDL Receptor antibody [VLDLR/1337] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human pancreas tissue stained with ARG41409 anti-VLDL Receptor antibody [VLDLR/1337]. Antigen Retrieval: Boil tissue section in 10 mM Tris with 1 mM EDTA (pH 9.0) for 10-20 min, followed by cooling at RT for 20 min.
