ARG45828
anti-Zebrafish ABCB11 antibody
anti-Zebrafish ABCB11 antibody for IHC-Formalin-fixed paraffin-embedded sections and Zebrafish
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ABCB11 |
|---|---|
| Tested Reactivity | Zfsh |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ABCB11 |
| Antigen Species | Zebrafish |
| Conjugation | Un-conjugated |
| Alternate Names | ABCB11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; SPGP; ABC16; BRIC2; PGY4; Bile salt export pump; PFIC2; PFIC-2; ATP-binding cassette sub-family B member 11; BSEP |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.02% Sodium azide and 50% glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% glycerol |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | ABCB11 |
|---|---|
| Gene Full Name | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008] |
| Function | Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. [UniProt] |
| Cellular Localization | Endosomeautomatic annotation; Membrane. [UniProt] |
| Calculated MW | 146 kDa |
| PTM | Ubl conjugation. [UniProt] |
