ARG45839
anti-Zebrafish KIAA1199 antibody
anti-Zebrafish KIAA1199 antibody for IHC-Formalin-fixed paraffin-embedded sections and Zebrafish
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KIAA1199 |
|---|---|
| Tested Reactivity | Zfsh |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KIAA1199 |
| Antigen Species | Zebrafish |
| Conjugation | Un-conjugated |
| Alternate Names | CEMIP; Cell Migration Inducing Hyaluronidase 1; KIAA1199; HYBID; TMEM2L; CEMIP1; Hyaluronan-Binding Protein Involved In Hyaluronan Depolymerization; Cell Migration-Inducing And Hyaluronan-Binding Protein; Cell Migration Inducing Protein, Hyaluronan Binding; Cell Migration Inducing Hyaluronan Binding Protein; IR2155535; Hyaluronan Binding Protein Involved In Hyaluronan Depolymerization; Colon Cancer Secreted Protein 1; EC 3.2.1.35; CCSP1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | 0.02M PBS, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% glycerol |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CEMIP |
|---|---|
| Gene Full Name | Cell Migration Inducing Hyaluronidase 1 |
| Background | Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of protein targeting to membrane. Located in several cellular components, including clathrin-coated endocytic vesicle; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Feb 2025] |
| Function | Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.. [UniProt] |
| Cellular Localization | Cell membrane; Coated pit; Cytoplasm; Endoplasmic reticulum; Membrane. [UniProt] |
| Calculated MW | 153 kDa |
| PTM | Glycoprotein. [UniProt] |
