ARG45861
anti-Zebrafish TFAP2A / AP2 alpha antibody
anti-Zebrafish TFAP2A / AP2 alpha antibody for IHC-Formalin-fixed paraffin-embedded sections and Zebrafish
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TFAP2A / AP2 alpha |
|---|---|
| Tested Reactivity | Zfsh |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TFAP2A / AP2 alpha |
| Antigen Species | Zebrafish |
| Conjugation | Un-conjugated |
| Alternate Names | TFAP2A; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); BOFS; TFAP2; Activating enhancer-binding protein 2-alpha; AP2-alpha; Transcription factor AP-2-alpha; AP-2; AP-2alpha; AP-2 transcription factor; Activator protein 2; AP2TF |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | 0.02M PBS, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% glycerol |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | TFAP2A |
|---|---|
| Gene Full Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| Background | The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] |
| Function | Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. [UniProt] |
| Calculated MW | 48 kDa |
| PTM | Sumoylated on Lys-10; which inhibits transcriptional activity. [UniProt] |
