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Tumor-infiltrating lymphocytes (TILs) are lymphocytes located around tumor cells. TILs have been identified in primary tumors, lymph nodes, and metastases. TILs have dual roles on tumor progression.
The anti-tumor immune responses involve cytotoxic T lymphocytes (CTLs) and NK cells for killing tumor cells, Th1 cells for enhancing cytotoxic effects of killer cells, and M1 tumor-associated macrophages (TAMs) for signaling and promoting inflammation and anti-tumor responses. On the other hand, the pro-cancer immune responses involves regulatory T cells (Tregs) for suppressing CTLs, and Th2 cells for suppression of killer cells and inducing differentiation of M2 TAMs which in turn promote tumor growth via secretion of growth factors.
Tumor-infiltrating lymphocytes (TILs) are not only a powerful prognostic marker but also a potential key breakthrough for anti-tumor therapy. arigo offers excellent antibodies to facilitate the pathological studies of TILs.
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