ARG30269
Apoptosis Marker Antibody Duo (Bcl2, Bid)
Publication18
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG20055 | anti-Bid antibody | Rabbit pAb | Hu | IHC, IP, WB | 25 μg |
| ARG55188 | anti-Bcl 2 antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
Overview
| Product Description | Bcl2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid protein is a member of the BCL2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. (provided by RefSeq, Jul 2008) Bcl2, BID and Bax are known to play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. Therefore, anti-Bcl2, Bid and Bax antibodies have been used in many cancer and cancer therapeutic studies. arigo provide an Apoptosis marker Duo, ARG30269, including anti-Bcl2 and anti-Bid antibodies, is useful for user to study the correlation of Bid, Bcl2 and apoptosis. |
|---|---|
| Target Name | Apoptosis Marker |
| Alternate Names | Apoptosis Marker antibody; Bid antibody; Bcl 2 antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Specific References
Honokiol attenuates mitochondrial fission and cell apoptosis by activating Sirt3 in intracerebral hemorrhage
ARG55188: WB / Rat
Resveratrol improves ovarian state by inhibiting apoptosis of granulosa cells
ARG55188: WB / Human
Dapagliflozin-entresto protected kidney from renal hypertension via downregulating cell-stress signaling and upregulating SIRT1/PGC-1α/Mfn2-medicated mitochondrial homeostasis
ARG55188: WB / Rat
Ivabradine could not decrease mitral regurgitation triggered atrial fibrosis and fibrillation compared with carvedilol
ARG55188: WB / Rat
Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease-Related Pulmonary Arterial Hypertension
ARG55188: WB / Human
Probucol attenuates high glucose-induced Müller cell damage through enhancing the Nrf2/p62 signaling pathway
ARG55188: WB / Human
Orlistat Resensitizes Sorafenib-Resistance in Hepatocellular Carcinoma Cells through Modulating Metabolism
ARG55188:WB / Human
Deletion of MicroRNA-21 Impairs Neovascularization Following Limb Ischemia: From Bedside to Bench
ARG55188: WB / Mouse
Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1
ARG55188: WB / Rat
Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4'-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2'-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers
ARG55188: WB / Human
Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis.
ARG55188: WB / Human
Dapagliflozin Improves Cardiac Hemodynamics and Mitigates Arrhythmogenesis in Mitral Regurgitation-Induced Myocardial Dysfunction.
ARG55188: WB / Rat
Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling
ARG55188: WB / Human
Xenogeneic and Allogeneic Mesenchymal Stem Cells Effectively Protect the Lung Against Ischemia-reperfusion Injury Through Downregulating the Inflammatory, Oxidative Stress, and Autophagic Signaling Pathways in Rat.
ARG55188: WB / Human
miR-371b-5p promotes cell proliferation, migration and invasion in non-small cell lung cancer via SCAI
ARG55188: WB / Human
A LY-15, a novel cyclic pentapeptide that inhibits B16 cell proliferation and migration and induces cell apoptosis
ARG55188: WB / Mouse
Possible Involvement of PTEN Signaling Pathway in the Anti-apoptotic Effect of Electroacupuncture Following Ischemic Stroke in Rats
ARG55188: WB / Rat
Electroacupuncture Alleviated Neuronal Apoptosis Following Ischemic Stroke in Rats via Midkine and ERK/JNK/p38 Signaling Pathway.
ARG55188: WB / Rat
