ARG30246
CARM1 mediated histone arginine methylation Antibody Duo (H3R17me2a, H3R26me2a)
Gene Regulation antibody
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG54785 | anti-Histone H3 dimethyl (Arg17) (asymmetric) antibody | Rabbit pAb | Hu, Ms, Rat | Dot, ICC/IF, IHC-P, WB | 50 μl |
| ARG54793 | anti-Histone H3 dimethyl (Arg26) (asymmetric) antibody | Rabbit pAb | Hu | Dot, ICC/IF, WB | 50 μl |
Overview
| Product Description | Arginine methylation is a common posttranslational modification occurs in various proteins. In particular, histone arginine methylation has been shown to promote or prevent docking of key transcriptional effector molecules, hence exerting a regulatory effect based on the modification of histone code. CARM1 (PRMT4) specifically methylates histone H3 at H3R17me2a and H3R26me2a sites. H3R17me2a serves as transcription activation mark, while the function of H3R26me2a modification is still under studied. An interesting feature of the H3R26 site is its proximity to a major repressive mark, H3K27me3. Further studies on how H3R26me2a affects function of Polycomb repression will have to be performed. |
|---|---|
| Target Name | CARM1 mediated histone arginine methylation |
| Alternate Names | CARM1 mediated histone arginine methylation antibody; Histone H3 dimethyl (Arg17) (asymmetric) antibody; Histone H3 dimethyl (Arg26) (asymmetric) antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | HIST1H3J |
|---|---|
| Gene Full Name | Antibody Duo for CARM1 mediated histone arginine methylation |
| Background | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [UniProt] |
| Research Area | Gene Regulation antibody |
