ARG83496
Canine CST3 / Cystatin C ELISA Kit
Canine CST3 / Cystatin C ELISA Kit for ELISA and Dog
Overview
| Product Description | ARG83496 Canine CST3 / Cystatin C ELISA Kit is an Enzyme Immunoassay kit for the quantification of Canine CST3 / Cystatin C in Plasma, Serum and Urine |
|---|---|
| Tested Reactivity | Dog |
| Tested Application | ELISA |
| Target Name | CST3 / Cystatin C |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 0.0625 ng/ml |
| Sample Type | Plasma, Serum and Urine |
| Standard Range | 0.125 - 4 ng/ml |
| Sample Volume | 100 μl |
| Precision | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| Alternate Names | CST3; Cystatin C; Neuroendocrine Basic Polypeptide; Post-Gamma-Globulin; Gamma-Trace; Cystatin-C; Cystatin C (Amyloid Angiopathy And Cerebral Hemorrhage); Epididymis Secretory Protein Li 2; BA218C14.4 (Cystatin C); Cystatin 3; Cystatin-3; HEL-S-2; ARMD11 |
Application Instructions
| Assay Time | 2 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 4°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CST3 |
|---|---|
| Gene Full Name | cystatin C |
| Background | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. |
| Function | As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. |
| Cellular Localization | Amyloid, Secreted |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein |
| Title | Download Link |
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| ARG83496 Canine CST3 / Cystatin C ELISA Kit User manual |
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